发明名称 |
MONOMERIC COMPOSITIONS EFFECTIVE AS WOUND CLOSURE DEVICES |
摘要 |
<p>A biocompatible monomer composition includes: (A) at least one monomer, which forms a medically acceptable polymer; (B) at least one plasticizing agent present in the composition in an amount of from 0.5 wt. to 15 wt. % of the composition; and (C) at least one acidic stabilizing agent having a pKa ionization constant of from about 1 to about 7. The composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together in vivo two surfaces, e.g., body tissues, includes (a) holding damaged tissue edges together to form abutted tissue surfaces; (b) applying to the abutted tissue surfaces an excessive amount of a composition containing 1) at least one monomer, which forms a medically acceptable biodegradable polymer, 2) at least one plasticizing agent; and 3) at least one acidic stabilizing agent; and (c) maintaining the surfaces in contact until the composition polymerizes to form a thick film of polymerized composition bridging the abutted tissue surfaces.</p> |
申请公布号 |
EP0886507(B1) |
申请公布日期 |
2007.09.26 |
申请号 |
EP19970907945 |
申请日期 |
1997.02.28 |
申请人 |
CLOSURE MEDICAL CORPORATION |
发明人 |
CLARK, JEFFREY, G.;LEUNG, JEFFREY, C. |
分类号 |
A61F13/00;A61B5/00;A61L24/00;A61L24/06;C08F2/44;C08F20/00;C08F20/42;C08F22/00;C08J5/12;C09J4/00;C09J7/00;G01J3/18 |
主分类号 |
A61F13/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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