发明名称 |
Retroviral vectors pseudotyped with influenza virus hemagglutinin for gene delivery |
摘要 |
<p>A retroviral delivery system capable of transducing a target site is described. The retroviral delivery system comprises a first nucleotide sequence coding for at least a part of an envelope protein; a second nucleotide sequence coding for at least a part of an envelope protein and one or more other nucleotide sequences derivable from a retrovirus that ensure transduction of the target site by the retroviral delivery system; wherein the first and second nucleotide sequences are heterologous with respect to at least one of the other nucleotide sequences; and wherein the first nucleotide sequence codes for at least a part of an influenza HA protein or a mutant, variant, derivative or fragment thereof that is capable of recognising the target site. Preferably said second protein is an influenza M2 protein.</p> |
申请公布号 |
EP1813676(A3) |
申请公布日期 |
2007.09.26 |
申请号 |
EP20070008912 |
申请日期 |
2003.02.04 |
申请人 |
OXFORD BIOMEDICA (UK) LIMITED;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
OLSEN, JOHN |
分类号 |
C12N15/86;A61K48/00;C07K14/11;C12N5/10;C12N7/00;C12N15/867 |
主分类号 |
C12N15/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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