发明名称 |
Microparticles for delivery of nucleic acid |
摘要 |
<p>Disclosed is a preparation of microparticles made up of a polymeric matrix and a nucleic acid expression vector. The polymeric matrix includes one or more synthetic polymers having a solubility in water of less than about 1 mg/1. At least 90% of the microparticles have a diameter less than about 100 microns. The nucleic acid is either RNA, at least 50% of which is in the form of closed circles, or circular DNA plasmid molecules, at least 50% of which are supercoiled.</p> |
申请公布号 |
EP1837017(A2) |
申请公布日期 |
2007.09.26 |
申请号 |
EP20070007764 |
申请日期 |
1998.01.22 |
申请人 |
EISAI INC. |
发明人 |
HEDLEY, MARY LYNN;CURLEY, JOANNE. M.;LANGER, ROBERT.S.;LUNSFORD,LYNN.B. |
分类号 |
A61K9/16;C12N15/09;A61K31/7088;A61K38/17;A61K48/00;A61P37/00;C12N5/10;C12N15/11;C12N15/87 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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