| 发明名称 |
CHIMERIC AND HUMANIZED ANTIBODIES TO ALPHA5 BETA1 INTEGRIN THAT MODULATE ANGIOGENESIS |
| 摘要 |
<p>The present invention provides chimeric and humanized antibodies that specifically recognize alpha5beta1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.</p> |
| 申请公布号 |
EP1575516(A4) |
申请公布日期 |
2007.09.26 |
| 申请号 |
EP20030796541 |
申请日期 |
2003.11.26 |
| 申请人 |
PDL BIOPHARMA, INC. |
发明人 |
RAMAKRISHNAN, VANITHA;POWERS, DAVID;JOHNSON, DALE E.;JEFFRY, URSULA |
| 分类号 |
C07K16/28;C07K16/42;(IPC1-7):A61K39/395;C07K16/46;C07K1/22;A61P27/00 |
主分类号 |
C07K16/28 |
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