发明名称 |
Triggered release of liposomal drugs following mixing of cationic and anionic liposomes |
摘要 |
Methods and compositions for triggering the delivery of an encapsulated therapeutic agent from a liposome are provided. Liposomes of opposite charge and incorporating lipids which favor non-lamellar structures are contacted in vivo. At least one of the liposome encapsulates at least one therapeutic drug or agent. Preferably, the liposomes have a fusogenic hydrophillic coating, such as PEG to control the rate of interaction of the liposomes and release of the therapeutic agent. |
申请公布号 |
US7273620(B1) |
申请公布日期 |
2007.09.25 |
申请号 |
US20030441781 |
申请日期 |
2003.05.19 |
申请人 |
UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
ZHIGALTSEV IGOR V.;WONG KIM F.;MAURER NORBERT;CULLIS PIETER R. |
分类号 |
A61K9/127 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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