| 发明名称 |
Nucleic acids encoding DP-178 and other viral fusion inhibitor peptides useful for treating aids |
| 摘要 |
The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1<SUB>LAI </SUB>gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
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| 申请公布号 |
US7273614(B2) |
申请公布日期 |
2007.09.25 |
| 申请号 |
US20030267682 |
申请日期 |
2003.01.06 |
| 申请人 |
DUKE UNIVERSITY |
发明人 |
BOLOGNESI DANI PAUL;MATTHEWS THOMAS JAMES;WILD CARL T. |
| 分类号 |
A61K39/21;C12N15/09;A61K38/00;A61K39/00;A61K39/12;A61K39/145;A61K39/155;A61K39/215;A61K39/245;A61K39/29;A61P31/12;A61P31/16;A61P31/18;C07K5/083;C07K5/087;C07K5/09;C07K5/093;C07K5/103;C07K5/107;C07K5/113;C07K5/117;C07K7/04;C07K14/005;C07K14/02;C07K14/025;C07K14/05;C07K14/11;C07K14/115;C07K14/12;C07K14/125;C07K14/13;C07K14/135;C07K14/15;C07K14/155;C07K14/16;C07K14/21;C07K14/22;C07K14/245;C07K14/285;C07K14/31;C12N9/94;C12N9/96;C12N9/98;C12N9/99;G01N33/50 |
主分类号 |
A61K39/21 |
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