| 摘要 |
An enzymatic method for preparing optically active 3-hydroxy-3-phenylpropionic acids is provided to improve optical purity and reaction easiness of the target compounds, and enhance separation and recovery of the produced compounds by using enzyme. And optically active 3-acyloxy-3-phenylpropionic acid is provided to be usefully used as intermediates of chiral medicines including tomoxetine and fluoxetine. An enzymatic method for preparing optically active 3-hydroxy-3-phenylpropionic acids represented by the formula(3) and optically active 3-acyloxy-3-phenylpropionic acid represented by the formula(4) comprises the steps of: preparing racemic 3-acyloxy-3-phenylpropionic acid represented by the general formula(2) from racemic-3-hydroxy-3-phenylpropionic acid represented by the general formula(1); and hydrolyzing the racemic 3-acyloxy-3-phenylpropionic acid represented by the general formula(2) in aqueous solution or organic solvent by using an enzyme selected from lipase, esterase and protease or a microorganism containing the enzyme in the reaction formula(1), wherein R=CnH2n+1, and n=1 to 8.
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