| 摘要 |
Use of bacterial strains of the species Amycolatopsis mediterranei for microbial transformation of 9beta,10alpha-steroids of formula (I) to their corresponding 11beta-hydroxyl analogues, as well as specific strains of that species, a process for transforming 9beta,10alpha-steroids to their corresponding 11beta-hydroxyl derivatives using bacterials strains of the species Amycolatopsis mediterranei, and subsequent isolation of the 11beta-hydroxyl derivatives from the bacterial culture medium. The resulting 11beta-hydroxylated products are useful intermediates for preparing novel steroidal compounds with 9beta,10alpha-confirmation carrying different kinds of substituents in the 11beta-position.
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