Substituted 3-cyanoquinolines as MEK inhibitors

摘要

The invention concerns quinoline derivatives of Formula (I) wherein each of Z¹, m, R¹, n, R³, Z² and R¹⁴ have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive or anti-proliferative agent in the containment and/or treatment of solid tumour disease.