| 摘要 |
PROBLEM TO BE SOLVED: To provide a novel 1-fluoro-1,1-bis(arylsulfonyl)methane useful for monofluoromethylation and its manufacturing method. SOLUTION: The method for manufascturing a fluorobis(arylsulfonyl)methane represented by formula (2): (ArSO<SB>2</SB>)<SB>2</SB>CHF (wherein Ar is a substituted or nonsubstituted phenyl group or naphthyl group)comprises treating a bis(arylsulfonyl)methane represented by formula (1): (ArSO<SB>2</SB>)<SB>2</SB>CH<SB>2</SB>(wherein Ar is the same as defined above) with a base, and then adding a fluorinating reagent, and the fluorobis(arylsulfonyl)methane represented by the above formula (2) is a novel compound very useful for manufacturing monofluoromethylated compounds. COPYRIGHT: (C)2007,JPO&INPIT
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