发明名称 |
Covalently immobilized protein gradients in three-dimensional porous scaffolds |
摘要 |
The invention provides a method for forming an immobilized agent gradient within a 3-dimensional porous scaffold. A 3-dimensional scaffold formed from a biocompatible material is provided. The surface of the scaffold and/ or the agent is activated so as to allow binding of the agent to the scaffold. The activated scaffold is contacted with a solution containing the agent. Contact with the solution is maintained for a sufficient period of time to allow diffusion of the solution through a portion of the scaffold, thereby forming a desired gradient of the agent through the 3-dimensional scaffold.
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申请公布号 |
US2007212730(A1) |
申请公布日期 |
2007.09.13 |
申请号 |
US20060407373 |
申请日期 |
2006.04.19 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
VEPARI CHARU;KAPLAN DAVID L.;VUNJAK-NOVAKOVIC GORDANA |
分类号 |
G01N33/53;C12M1/34 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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