发明名称 |
SPECIFIC AMPLIFICATION OF FETAL DNA SEQUENCES FROM A MIXED, FETAL-MATERNAL SOURCE |
摘要 |
The present invention provides a method of selectively amplifying fetal DNA sequences from a mixed, fetal-maternal source. This method utilizes differential methylation to allow for the selective amplification of trophoblast/fetal specific sequences from DNA mixtures that contain a high proportion of non-trophoblast/fetal DNA. The invention also provides methods of using the amplified fetal DNA sequences for aneuploidy detection. |
申请公布号 |
CA2645045(A1) |
申请公布日期 |
2007.09.13 |
申请号 |
CA20072645045 |
申请日期 |
2007.03.06 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY |
发明人 |
BROWN, STEPHEN |
分类号 |
C12P19/34;C12N15/87;C12Q1/68 |
主分类号 |
C12P19/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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