XAF-1, A DIAGNOSTIC MARKER FOR INTERFERON RESPONSIVENESS IN MULTIPLE SCLEROSIS

摘要

Disclosed is a method of determining interferon responsiveness in a patient suffering from multiple sclerosis (MS). The method comprises determining an amount of a X linked inhibitor of apoptosis protein associated factor - 1 (XAF-1) gene expression level in a blood sample, which is obtained from the patient undergoing interferon (IFN) therapy. The amount of the XAF-1 gene expression level in the blood sample is then correlated with the responsiveness of the patient to interferon.