发明名称 |
PROCESS |
摘要 |
A process for the preparation of a compound of Formula (1) wherein Ar represents an optionally substituted hydrocarbyl or an optionally substituted heterocyclyl group comprising an aromatic moiety; and R 1 and R2 each independently represent an optionally substituted hydrocarbyl or an optionally substituted heterocyclyl group; said process comprising: a) reducing a compound of Formula (2) to form a compound of Formula (3): b) activating the compound of Formula (3) to form a compound of Formula (4): wherein OX represents a leaving group; and c) coupling the compound of Formula (4) to a compound of Formula (5): to form a compound of Formula (1). A stereoselective reduction of ketones to alcohols is also disclosed. |
申请公布号 |
KR20070092298(A) |
申请公布日期 |
2007.09.12 |
申请号 |
KR20077016849 |
申请日期 |
2007.07.20 |
申请人 |
AVECIA PHARMACEUTICALS LIMITED |
发明人 |
HODGES GEORGE ROBERT;MARTIN JULIETTE;HAMMIL NOEL ANTHONY;HOUSON IAN NICHOLAS |
分类号 |
C07C211/29;C07C29/143;C07C33/20;C07C209/16 |
主分类号 |
C07C211/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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