发明名称 |
GENETIC VARIANTS OF VKORC1 PREDICTING WARFARIN SENSITIVITY |
摘要 |
We discovered that a polymorphism in the promoter of the VKORCI gene is associated with warfarin sensitivity. This polymorphism can explain both the interindividual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORCI gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided. |
申请公布号 |
EP1831402(A2) |
申请公布日期 |
2007.09.12 |
申请号 |
EP20050855433 |
申请日期 |
2005.12.21 |
申请人 |
ACADEMIA SINICA |
发明人 |
CHEN, YUAN-TSONG;YUAN, HSIANG-YU;CHEN, JIN-JER |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|