Compositions based on Midkine for the treatment of chronic stage injury of the heart after ischemia/reperfusion
摘要
<p>The present inventors compared myocardial damages after ischemia/reperfusion in wild-type mice and Midkine (MK)-deficient mice to confirm the effects and functions of MK. MK administration was found to significantly prevent cardiomyocyte apoptosis in both cultured cardiomyocytes (in vitro) and mouse models ( in vivo ) .</p>
申请公布号
EP1832296(A1)
申请公布日期
2007.09.12
申请号
EP20050814479
申请日期
2005.12.06
申请人
CELL SIGNALS INC.;NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY