| 摘要 |
The present invention discloses a self-contained miniature biosensor designed to detect specific molecular targets, and in particular polypeptides and polynucleotides. For example, hybridized nucleic acids may be detected without external monitoring or signal transmission. The miniaturized biosensor comprises multiple biological sensing elements such as DNA probes, excitation microlasers, a sampling waveguide equipped with optical detectors (fluorescence and Raman), integrated electro-optics, and a biotelemetric radio frequency signal generator all contained on a single integrated circuit, or "biochip". The novel integrated circuit biochip microsystem (ICBM) is suitable for gene analysis and will allow rapid, large-scale, and cost-effective production of biochips useful in the detection of biological compositions, including the development of multi-array gene chips.
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