发明名称 |
Compositions for rapid and non-irritating transdermal delivery of pharmaceutically active agents and methods for formulating such compositions and delivery thereof |
摘要 |
A transdermal delivery system (TDS)for use in treatment of living bodies may be applied as an open (liquid, gel) or closed (patch) article. The TDS is composed of a particular active agent which dictates an associated selection of certain solvents, solvent modifiers, solute modifiers and skin stabilizers with which the medicament forms a true solution that rapidly crosses the skin barrier. The associated selection of the particular solvents, solvent modifiers, solute modifiers and skin stabilizers is based on a balancing of the molecular properties of all the components against the molecular properties of all the components plus the particular active agent. The TDS may also include a source of cellular energy to induce CAMP or cGMP. The TDS improves delivery of active agents having a molecular weight greater than 340 Daltons and increases dosage above 0.25 mg/day for such active agents.
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申请公布号 |
US7267829(B2) |
申请公布日期 |
2007.09.11 |
申请号 |
US20040831416 |
申请日期 |
2004.04.23 |
申请人 |
TRANSDERMAL TECHNOLOGIES, INC. |
发明人 |
KIRBY KENNETH B;PETTERSSON BERNO |
分类号 |
A61F13/00;A61K9/00;A61K8/00;A61K8/31;A61K8/33;A61K8/34;A61K8/36;A61K8/37;A61K8/41;A61K8/46;A61K8/49;A61K8/60;A61K8/96;A61K8/97;A61K8/98;A61K8/99;A61K36/00;A61K36/232;A61K36/324;A61K36/53;A61K36/74;A61K47/10;A61K47/12;A61K47/46;A61L15/16;A61L15/44;A61P17/00;A61Q19/00 |
主分类号 |
A61F13/00 |
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