METHOD FOR APPLYING PHOTODYNAMIC THERAPY AND REMOVING CHOROID MELANOMA

摘要

FIELD: medicine. ^ SUBSTANCE: method involves intravenously introducing chlorine row photosensitizer in water-soluble form at a dose of 0.8-1.1 mg/kg x 0.7 during 10 min. Spectral fluorescent diagnostic procedure for determining photosensitizer accumulation in intraocular neoplasm, is carried out in 1 h after having finished chlorine row photosensitizer introduction. Then, chlorine row photosensitizer in liposomal form is intravenously introduced in bolus dose of 0.8-1.1 mg/kg x 0.3. 10 min later, tumor periphery is transpupillarily exposed to laser radiation of 670 nm wavelength all over its perimeter with power density of 60-80 J/cm. Next to it, the whole neoplasm surface is transpupillarily irradiated with laser radiation of 662 nm wavelength and power density of 100-120 J/cm. Irradiation is carried out in circularly moving from periphery towards the center. The treatment is applied field-by-field with neighboring fields overlay by 5% of area. The intraocular neoplasm is removed 2 weeks later. ^ EFFECT: enhanced effectiveness in destroying blood vessels feeding the tumor; destroyed tumor cells; complete removal of intraocular neoplasm; no intraoperative bleeding from tumor blood vessels; reduced risk of tumor cells revival, relapses and metastases. ^ 2 cl