发明名称 |
Substituerede 8'-pyri(mi)dinyldihydrospiro[cycloalkylamin]-pyrimido[1,2-a]pyrimidin-6-onderivater |
摘要 |
<p>The invention relates to a dihydrospiro-ÄcycloalkylamineÜ-pyrimidone derivative represented by formula (I) or a salt thereof: <CHEM> wherein: X represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom; Y represents a bond, a carbonyl group, a methylene group optionally substituted; R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring, the ring being optionally substituted; R2 represents a benzene ring or a naphthalene ring; the rings being optionally substituted; R3 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom; R4 represents a hydrogen atom, a C1-4 alkoxy carbonyl group, a C1-6 alkyl group optionally substituted; o and m represent 1 to 2; n represents 0 to 3; p represents 0 to 2; and q represents 0 to 2. <??>The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3 beta , such as Alzheimer disease.</p> |
申请公布号 |
DK1699795(T3) |
申请公布日期 |
2007.09.10 |
申请号 |
DK20040804431T |
申请日期 |
2004.12.17 |
申请人 |
SANOFI-AVENTIS;MITSUBISHI PHARMA CORPORATION |
发明人 |
CHEREZE, NATHALIE;LOCHEAD, ALISTAIR;SAADY, MOURAD;SLOWINSKI, FRANCK;YAICHE, PHILIPPE |
分类号 |
C07D487/04;A61K31/505;A61P25/28 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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