YEAST CAPABLE OF PRODUCING SELENOMETHIONINE-CONTAINING PROTEIN

摘要

A novel Pichia yeast capable of producing a selenomethionine-containing protein can be produced by imparting an L-selenomethionine-resistance to a selenomethionine-sensitive Pichia yeast by natural mutation. A yeast having a good ability of producing an L-selenomethionine-containing protein can be produced by introducing a methionine aminoacyl-tRNA synthetase gene into aPichia yeast. Thus, it becomes possible to produce an L-selenomethionine-containing (selenomethionine-containing) protein in a large amount.