发明名称 |
ATTENUATED REOVIRUS |
摘要 |
<p>Compositions and methods are provided that relate to an attenuated reovirus exhibiting oncolytic activity toward cancer cells while displaying reduced lytic activity toward non-malignant cells. Exemplified is an attenuated human reovirus derived from persistently infected fibrosarcoma cells that lacks wild-type reovirus S1 and S4 genes and consequently lacks a detectable reoviral outer capsid sigma1 protein and expresses a mutated reoviral outer capsid sigma3 protein.</p> |
申请公布号 |
CA2617600(A1) |
申请公布日期 |
2007.09.07 |
申请号 |
CA20062617600 |
申请日期 |
2006.07.31 |
申请人 |
UNIVERSITY TECHNOLOGIES INTERNATIONAL, INC. |
发明人 |
JOHNSTON, RANDAL N.;KIM, MANBOK |
分类号 |
C12N7/01;A61K35/76;A61K39/15;A61P35/00;C07K14/14;C12N7/04;C12N15/46;C12N15/86 |
主分类号 |
C12N7/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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