发明名称 |
CLEAVAGE OF ANTIFOLATE COMPOUNDS |
摘要 |
A method of combating toxicity caused by an antifolate compound of Formula I, in an individual who has been administered the compound. The method comprises administering an enzyme that has carboxypeptidase G activity to the individual. A method of cleaving a compound comprising a structural fragment of Formula IV, the method comprising contacting the compound comprising the structural fragment of Formula IV with an enzyme that has carboxypeptidase G activity. |
申请公布号 |
WO2007023243(A3) |
申请公布日期 |
2007.09.07 |
申请号 |
WO2005GB03297 |
申请日期 |
2005.08.24 |
申请人 |
PROTHERICS MEDICINES DEVELOPMENT LIMITED;MELTON, ROGER;ATKINSON, ANTHONY |
发明人 |
MELTON, ROGER;ATKINSON, ANTHONY |
分类号 |
A61K38/48;A61K31/505;A61P35/00 |
主分类号 |
A61K38/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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