A MOLECULE AND CHIMERIC MOLECULES THEREOF

摘要

The present invention relates generally to the fields of proteins, diagnostics, therapeutics and nutrition. More particularly, the present invention provides an isolated protein molecule that comprises a type I cytokine family receptor protein, such as erythropoietin receptor (EPOR), granulocyte colony-stimulating factor receptor (G-CSFR), granulocyte-macrophage colony-stimulating factor receptor alpha subunit (GM-CSFR), cytokine receptor common beta chain (CRC beta) or a ligand thereof, such as oncostatin-M (OSM) and thrombopoietin (TPO), or chimeric molecules thereof comprising at least a portion of the protein molecule, such as EPOR-Fc, G-CSFR-Fc, GM-CSFR-Fc, CRC beta-Fc; wherein the protein or chimeric molecule thereof has a profile of measurable physiochemical parameters, wherein the profile is indicative of, associated with or forms the basis of one or more pharmacological traits. The present invention further contemplates the use of the isolated protein or chimeric molecule thereof in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications.