摘要 |
Disclosed are methods involving the administration of an extracellular matrix (ECM)/metastasis modifier gene, e.g., Anakin, Necdin, CentaurinD3 (CentD3), Csf1r, Brd4, Pi16, and Luc7l, for the prevention or inhibition of metastasis or of tumor growth. Further disclosed are methods of characterizing a tumor or cancer in a subject comprising detecting (i) a single nucleotide polymorphism (SNP) in an Anakin gene or a Brd4 gene of the subject, (ii) an amino acid substitution in an Anakin protein in the subject, or (iii) a level of expression of an Anakin gene or a Brd4 gene in the subject. Methods of screening a compound for anti-cancer activity and use of a compound with anti-cancer activity for the preparation of a medicament to treat or prevent cancer in a subject are also disclosed. Also disclosed is a method of inhibiting Sipa-1 in a subject. |
申请人 |
GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;HUNTER, KENT W.;CRAWFORD, NIGEL;LOWY, DOUGLAS R.;QIAN, XIAOLAN;ANTON-CULVER, HODA;ZIOGAS, AGRYRIOS |
发明人 |
HUNTER, KENT W.;CRAWFORD, NIGEL;LOWY, DOUGLAS R.;QIAN, XIAOLAN;ANTON-CULVER, HODA;ZIOGAS, AGRYRIOS |