A rapid and sensitive radiometric assay for assessing the activity of cytochrome P-450 (CYP) 2C19 and the potential of an analyte to inhibit CYP2C19 activity or induce CYP2C19 expression is described. All the steps of the assay, including incubations, product separation, and radioactivity counting are preferably performed in a multiwell format, which can be automated.
申请公布号
WO2007035335(A3)
申请公布日期
2007.09.07
申请号
WO2006US35529
申请日期
2006.09.13
申请人
MERCK & CO., INC.;ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.;LAUFER, RALPH;DI MARCO, ANNALISE;CHAUDHARY, ASHOK
