| 摘要 |
The object is to provide a method for detaching a 2-cyanoethoxymethoxy (CEM) group substituted on a position-2 hydroxyl group in a ribose with good reproducibility and high efficiency. Disclosed is a process for detaching a protecting group located on a position-2 hydroxyl group in each of riboses in an oligonucleic acid derivative represented by the general formula (10) by reacting the derivative with TBAF, wherein a sulfoxide solvent, an amide solvent or a mixture thereof is used as a reaction solvent, thereby producing an oligonucleic acid derivative represented by the general formula (11). |
