The invention provides for a method for aggregating dermal papilla cells or dermal sheath cells or a combination thereof, the method comprising: growing dermal papilla cells or dermal sheath cells or a combination thereof in suspension culture; and contacting the culture with an effective amount of an enzyme, wherein a substrate of the enzyme is an extracellular matrix molecule in the suspension culture, so as to aggregate dermal papilla cells or dermal sheath cells. The culture may be a hanging drop culture and the enzyme may be a hyaluronidase.
申请公布号
WO2007100870(A2)
申请公布日期
2007.09.07
申请号
WO2007US05193
申请日期
2007.02.28
申请人
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;CHRISTIANO, ANGELA, M.;JAHODO, COLIN, A., B.