USE OF CK2 INHIBITOR FOR THE TREATMENT AND CHEMOSENSIBILIZATION OF REFRACTORY TUMORS TO ANTICANCER DRUGS

摘要

The present invention relates to a pharmaceutical combination that includes a casein kinase 2 phosphorylation inhibitor (called p15) and cytostatics used in cancer chemotherapy, which are administered simultaneously, separately or sequentially. The preferred cytostatics are platinums, taxans, vinca alkaloids, 5-fluorouracil, doxorubicin, cyclophosphamide, etoposide, mitomycin C, imatinib, iressa and velcade (bortezomib). Synergy between peptide p15 and the anticancer chemical compounds means that the effective concentration of each cytostatic in the combination is between 1 and 2 orders of magnitude less than that corresponding to cytostatics alone. Consequently, the combination described in the invention has a much lower toxicity than that reported for anticancer cytostatics, which represents a crucial advantage in their use in cancer treatment. Additionally, administered sequentially, the combination gives rise to the chemosensitization of refractory tumours to the cytostatics mentioned by means of pre-treatment with peptide p15.