| 摘要 |
The present invention relates to a group of novel tetrahydropyridin-4-yl indoles with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine-D2 receptors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said tetrahydropyridin-4-yl indoles. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The invention relates to novel tetrahydropyridin-4-yl indoles of the formula (I) and tautomers, stereoisomers, prodrugs, N-oxides, pharmacologically acceptable salts, hydrates and solvates thereof, wherein:-R1 is hydrogen, halogen, alkyl (C1-3) or alkoxy(C1-3), CN or CF 3,-R2 is hydrogen or alkyl (C1-3), R 3 is hydrogen or alkyl (C1-3),-Z is hydrogen or alkyl (C1-3), alkoxy(C1-3) or alkylthio(C1-3),-A is hydrogen or alkyl (C1-3), or-A and Z together form a saturated or (partly) unsaturated 5-or 6-membered ring which may be substituted with halogen, alkyl (C1-3) or phenyl, in which ring Z represents carbon, sulfur of nitrogen. |
