发明名称 |
2-(Phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors |
摘要 |
The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
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申请公布号 |
US2007208017(A1) |
申请公布日期 |
2007.09.06 |
申请号 |
US20050374288 |
申请日期 |
2005.11.23 |
申请人 |
CHAU ANH;COTE BERNARD;DUCHARME YVES;FRENETTE RICHARD;FRIESEN RICHARD;GAGNON MARC;GIROUX ANDRE;MARTINS EVELYN;YU HONGPING;WU TOM |
发明人 |
CHAU ANH;COTE BERNARD;DUCHARME YVES;FRENETTE RICHARD;FRIESEN RICHARD;GAGNON MARC;GIROUX ANDRE;MARTINS EVELYN;YU HONGPING;WU TOM |
分类号 |
A61K31/5377;A61K31/4188;A61K31/4245;A61K31/4439;C07D403/14;C07D413/14 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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