PROCESS FOR PREPARING INTERMEDIATES FOR THE MANUFACTURE OF DISCODERMOLIDE AND DISCODERMOLIDE ANALOGUES

摘要

The invention relates to a process for the preparation of a substituted alkene of formula (I) wherein R₁, R₂ and R₃ are independently of each other a protecting group for a hydroxy group or hydrogen and R₄ is phenyl which is unsubstituted or mono- or disubstituted by alkoxy, which alkene constitutes an intermediate for the preparation of discodermolide and discodermolide analogues.