| 摘要 |
A delivery device and method for delivering substances as an aerosol to a subject via the nasal or oral mucosae. The delivery device comprising a nozzle for directing the aerosol at the mucosa, and a substance supply unit, characterised in that at least a fraction of the aerosol particles have a dimension and velocity such as to penetrate the mucosa. The nozzle may include a nosepiece which may be inflatable and has the effect of directing the aerosol at the mucosa. Actuation may be triggered in response to proximity to the mucosal surface or in response to breath or exhalation. A second delivery unit may deliver another substance to the other nostril. Also claimed is a delivery device comprising a nozzle and nosepiece wherein actuation is associated with initiation of the Hering-Breuer reflex by providing a flow of gas at the face of the user. |
