发明名称 |
Method and composition for inhibiting cancer cell growth |
摘要 |
Improvements in methods of treating cancer with weakly basic anti-cancer compounds are provided. In one aspect, the invention provides an improvement in a method of treating cancer cells whose extracellular environment contains 1-8 mM urea, by exposing the cells to a weakly basic anti-cancer compound which is effective in inhibiting the growth of the cells. The improvement includes (a) exposing the cells to a urease enzyme composition and, (b) by step (a), reducing the amount of anti-cancer compound required to produce a given extent of inhibition in the growth of the cells when the cells are exposed to the anti-cancer agent. Methods of potentiating the specific therapeutic activity of a weakly basic anti-cancer compound in the treatment of a given mammalian cancer which is responsive to the compound are provided as are pharmaceutical compositions for use in intravenous administration to a subject are also provided.
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申请公布号 |
US7264800(B2) |
申请公布日期 |
2007.09.04 |
申请号 |
US20050046271 |
申请日期 |
2005.01.27 |
申请人 |
HELIX BIOPHARMA CORPORATION |
发明人 |
SEGAL DONALD;MCELROY JERRY;CHAO HEMAN;WONG WAH Y.;DOCHERTY JOHN;DICKSTEIN JODI |
分类号 |
A61K38/46;A61K38/50;A61K47/48;A61K48/00;C12N9/78;C12Q1/58 |
主分类号 |
A61K38/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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