| 发明名称 |
THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS |
| 摘要 |
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein. (I)
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| 申请公布号 |
UA80131(C2) |
申请公布日期 |
2007.08.27 |
| 申请号 |
UA20041209867 |
申请日期 |
2003.05.28 |
| 申请人 |
3-DIMENSIONAL PHARMACEUTICALS, INC. |
发明人 |
SUBASINGHE NALIN;KHALIL EHAB;LEONARD KRISTI;ALI FARAH;HUFNAGEL HEATHER RAE;TRAVINS JEREMY M.;BALLENTINE SHELLEY K.;WILSON KENNETH T.;CUMMINGS MAXWELL D.;PAN WENXI;GUSHUE JOAN;MEEGALLA SANATH;WALL MARK;CHEN JINSHENG;RUDOLPH M. JONATHAN;HUANG HUI |
| 分类号 |
A61K31/381;C07D333/22;A61K31/404;A61K31/41;A61K31/416;A61K31/417;A61K31/4178;A61K31/4184;A61K31/4188;A61K31/422;A61K31/427;A61K31/428;A61K31/443;A61K31/4436;A61K31/4439;A61K31/444;A61K31/453;A61K31/4535;A61K31/4709;A61K31/496;A61K31/497;A61K31/506;A61K31/513;A61K31/537;A61K31/5377;A61K31/662;A61P1/04;A61P3/10;A61P5/14;A61P5/48;A61P7/00;A61P7/06;A61P7/08;A61P7/10;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P13/02;A61P13/12;A61P17/00;A61P17/02;A61P17/06;A61P19/02;A61P19/10;A61P21/04;A61P25/00;A61P25/28;A61P29/00;A61P31/00;A61P31/04;A61P37/00;A61P37/06;A61P37/08;A61P41/00;A61P43/00;C07D333/12;C07D333/38;C07D333/54;C07D409/12;C07D409/14;C07D413/12;C07D413/14;C07D417/12;C07D495/04;C07F7/08;C07F7/10;C07F9/655;C07F9/6553 |
主分类号 |
A61K31/381 |
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