发明名称 |
METHOD FOR COMPLEX TREATMENT OF SKIN MELANOMA |
摘要 |
FIELD: medicine, oncology. ^ SUBSTANCE: the present innovation deals with treating patients in case of skin melanoma stage III. For this purpose blood plasma should be incubated with the following chemopreparations: cisplatin 30 mg, metotrexate 5 mg, cyclophosphan 600 mg in a thermostat at 37°C for 30 min and in pre-surgical period it is necessary to inject it for a patient into subcutaneous fatty fiber due to paracenteses from 4 sides under the focus of malignant growth. During the same day it is important to star gamma-therapy at the dosage of 2.4 Gy daily for 5 d, then comes 1-d-long interval and the same order of procedures should be continued twice more. In 2 d one should carry out operation in the volume of wide dissecting the primary focus at regional lymphadenectomy. In 2 wk after operation - with the same preparations and at the same dosages 5 times every other week. During the next 2 yr it is necessary to carry out analogous adjuvant autohemochemotherapy once/3 mo. Application of the complex therapy suggested enables to achieve higher percentage of tumor regression, increase duration and improve quality of life. ^ EFFECT: higher efficiency of therapy. ^ 1 ex |
申请公布号 |
RU2304965(C2) |
申请公布日期 |
2007.08.27 |
申请号 |
RU20050110495 |
申请日期 |
2005.04.11 |
申请人 |
ROSTOVSKIJ NAUCHNO-ISSLEDOVATEL'SKIJ ONKOLOGICHESKIJ INSTITUT MZ RF;SIDORENKO JURIJ SERGEEVICH;DZHABAROV FARKHAD RASIMOVICH;ROZEKNO LJUDMILA JAKOVLEVNA;FRANTSIJANTS ELENA MIKHAJLOVNA;POZDNJAKOVA VIKTORIJA VADIMOVNA |
发明人 |
SIDORENKO JURIJ SERGEEVICH;DZHABAROV FARKHAD RASIMOVICH;ROZEKNO LJUDMILA JAKOVLEVNA;FRANTSIJANTS ELENA MIKHAJLOVNA;POZDNJAKOVA VIKTORIJA VADIMOVNA |
分类号 |
A61K31/196;A61B17/00;A61K31/282;A61K31/675;A61K35/16;A61M1/36;A61N5/10;A61P35/00 |
主分类号 |
A61K31/196 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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