PROCESS FOR PREPARING 3-(2-(4-(6-FLUOROBENZO(D) ISOXAZOL-3-YL)-PIPERIDIN-1YL)-ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO-(1,2-A) PYRIMIDIN-4-ONE AND DERIVATIVES

摘要

The process consists in condensing (2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a]pyrimidin-3-yl)-acetaldehyde with 6-fluoro-3-piperidinyl)-1,2-benzisoxazole to yield the intermediate enamine, 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-yl)-piperidin-1-yl)vinyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one followed by reduction of such an enamine.