发明名称 |
COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS |
摘要 |
<p>The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.</p> |
申请公布号 |
KR20070083836(A) |
申请公布日期 |
2007.08.24 |
申请号 |
KR20077009654 |
申请日期 |
2007.04.27 |
申请人 |
IRM LLC;THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
WU XU;DING SHENG;SCHULTZ PETER G. |
分类号 |
A61K31/542;A61K31/437;C12Q1/68 |
主分类号 |
A61K31/542 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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