发明名称 |
COMPOSITIONS AND METHODS FOR SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONIC STEM CELLS |
摘要 |
The present invention provides compositions and methods for the production of differentiated mammalian cells. More particularly, the present invention provides cellular differentiation methods employing culturing the cells on a feeder layer or under feeder-free conditions in cell culture and further contacting the cells with an inhibitor of the PI3-kinase pathway and a member of the TGFb family for the generation of differentiated mammalian cells from pluripotent mammalian stem cells. Preferably, the differentiated cell is selected from the group consisting of a mesendodermal cell, a mesodermal cell, and an endodermal cell.
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申请公布号 |
KR20070083559(A) |
申请公布日期 |
2007.08.24 |
申请号 |
KR20077005874 |
申请日期 |
2007.03.13 |
申请人 |
THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.;CYTHERA, INC. |
发明人 |
DALTON STEPHEN;SHEPPARD ALLAN;JONES KAREN;BAETGE E. EDWARD;D'AMOUR KEVIN A.;AGULNICK ALAN D. |
分类号 |
C12N5/00;C12N5/02;C12N5/0735 |
主分类号 |
C12N5/00 |
代理机构 |
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