发明名称 |
Immune Modulation By Regulating Expression Of The Minor Gene In Immune Dendritic Cells |
摘要 |
Mitogen induced nuclear orphan receptor (MINOR) is described as inducing apoptosis in dendritic cells (DCs). Downregulation of its expression results in a downregulation of apoptosis. A novel approach of inhibiting DC apoptosis is described employing small interfering RNA (siRNA) that targets MINOR. Improved DC-based vaccines exhibiting longer lifespan of DCs, increased potency of DCs, and enhanced immunogenicity are described.
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申请公布号 |
US2007196335(A1) |
申请公布日期 |
2007.08.23 |
申请号 |
US20050588888 |
申请日期 |
2005.02.09 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
PARDOLL DREW;WHARTENBY KATHARINE A.;GORSKI KEVIN S.;CHAN CAMIE |
分类号 |
A61K48/00;A61K39/00;C12N5/0784;C12N15/113 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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