发明名称 PROCESS FOR THE CYANATION OF IMINES
摘要 <p>The present invention relates to a process for the cyanation of imines, particularly to the asymmetric cyanation of imines. The Strecker reaction consists of a reaction between an aldehyde and an amine to form an imine, followed by the conversion of the imine to an alpha-amino nitrile by asymmetric catalysis. The present invention relates to a series of vanadium catalysts which allow the reduction of the imine in the Strecker reaction to be performed in good conversion and also with good ee values. The chiral catalysts are of formula (1a) or (1b).</p>
申请公布号 WO2007093764(A1) 申请公布日期 2007.08.23
申请号 WO2007GB00420 申请日期 2007.02.07
申请人 NPIL PHARMACEUTICALS (UK) LIMITED;ATHERTON, JOHN;BLACKER, JOHN;EDWARDS, NEIL;FROST, TIMOTHY, FAULKNER 发明人 ATHERTON, JOHN;BLACKER, JOHN;EDWARDS, NEIL;FROST, TIMOTHY, FAULKNER
分类号 B01J31/18;C07B57/00;C07C253/08 主分类号 B01J31/18
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