MORAXELLA POLYPEPTIDES AND CORRESPONDING DNA FRAGMENTS AND USES THEREOF

摘要

The present invention provides nucleic acids, proteins and vectors for immunization of a host, including humans, against disease caused by infection by a strain of Moraxella, specifically M. catarrhalis. The invention includes DNA vaccination methods which employ a vector containing a nucleotide sequence encoding a protein of a strain of Moraxella, specifically M. catarrhalis, and a promoter to effect expression of the protein gene product in the host. The nucleotide sequences include those which encode: a major anaerobically induced OMP, rare lipoprotein A proteins, component proteins of the adhesin complex, a potential lipoprotein OMP, a putative oxidoreductase, OprM, collagenase, outer membrane phopholipase A, lipoproteins, OmpA, NADH:ubiquinone oxidoreductase subunit, pilQ fimbriae, invasin protein, a 36 kDa secreted protein, OMP, Outer membrane esterase, pyridine nucleotide transhydrogenase, HecB, a putative virulence factor, heme receptor, ompC, heme receptor, and porin.