The invention provides antibodies or antigen binding fragments thereof to DR5 and HER-2. The antibodies and/ or antigen binding fragments thereof comprise variant CDRs comprising highly restricted amino acid sequence diversity. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. In addition, compositions and methods of use for treatment of cancer and immune related conditions are provided.
申请公布号
WO2007094842(A2)
申请公布日期
2007.08.23
申请号
WO2006US46046
申请日期
2006.12.01
申请人
GENENTECH, INC.;SIDHU, SACHDEV, S.;BIRTALAN, SARA, C.;FELLOUSE, FREDERIC, A.
发明人
SIDHU, SACHDEV, S.;BIRTALAN, SARA, C.;FELLOUSE, FREDERIC, A.