METHOD OF ENHANCING PROLIFERATION AND/OR HEMATOPOIETIC DIFFERENTIATION OF STEM CELLS
摘要
The present invention provides methods for inducing differentiation of a stem cell, such as an embryonic stem cell, into a hematopoietic stem cell, by expressing a cdx gene and/or a hox gene. The method is useful for generating expanded populations of hematopoietic stem cells (HSCs) and thus mature blood cell lineages. This is desirable where a mammal has suffered a decrease in hematopoietic or mature blood cells as a consequence of disease, radiation or chemotherapy.
申请公布号
WO2007002167(A8)
申请公布日期
2007.08.23
申请号
WO2006US24099
申请日期
2006.06.21
申请人
CHILDREN'S MEDICAL CENTER CORPORATION;DALEY, GEORGE, Q.;WANG, YUAN;YATES, FRANK;NAVEIRAS, OLAIA