TREATMENT OF CONDITIONS ASSOCIATED WITH THE PRESENCE OF MACROMOLECULAR AGGREGATES, PARTICULARLY OPHTHALMIC DISORDERS

摘要

A method and formulation are provided for the treatment of medical conditions associated with the formation and/or deposition of macromolecular aggregates, particularly those associated with adverse ocular conditions. The formulation contains a non-cytotoxic chelating agent containing at least three negatively charged chelating atoms and a charge-masking agent containing at least one polar group and having a molecular weight of less than about 250, wherein the molar ratio of the charge-masking agent to the chelating agent is sufficient to ensure that substantially all negatively charged chelating atoms are associated with a polar group on the charge-masking agent.