| 发明名称 |
Hyaluronic Acid-Methotrexate Conjugate |
| 摘要 |
An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.
|
| 申请公布号 |
US2007197465(A1) |
申请公布日期 |
2007.08.23 |
| 申请号 |
US20050591653 |
申请日期 |
2005.03.04 |
| 申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IKEYA HITOSHI;MORIKAWA TADASHI;TAKAHASHI KOICHI;TAMURA TATSUYA;OKAMACHI AKIRA;ISHIZAWA TAKENORI;SATO HARUHIKO;HIGUCHI YOSHINOBU |
| 分类号 |
A61K31/728;A61K31/519;A61K31/525;A61K47/48;A61P19/02;C07D475/10;C07K5/00;C07K9/00;C08B37/00;C08B37/08 |
主分类号 |
A61K31/728 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
