摘要 |
<p>This invention relates to novel chromen-2-one derivatives of formula (I) useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention. Formula (I) wherein Q represents a chromen-2-one group; which chromen-2-one group is optionally substituted with one or more substituents independently selected from the group consisting of: halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl; R<SUP>1</SUP> represents hydrogen or alkyl; which alkyl is optionally substituted with one or more substituents independently selected from the group consisting of: halo, trifluoromethyl, trifluoromethoxy, cyano, hydroxy, amino, nitro, alkoxy, cycloalkoxy, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl and alkynyl; and R<SUP>2</SUP> and R<SUP>3</SUP> together form -(CH<SUB>2</SUB>)-(CH<SUB>2</SUB>)- or -(CH)=(CH)-.</p> |
申请人 |
NEUROSEARCH A/S;PETERS, DAN;REDROBE, JOHN, PAUL;NIELSEN, ELSEBET, OESTERGAARD |
发明人 |
PETERS, DAN;REDROBE, JOHN, PAUL;NIELSEN, ELSEBET, OESTERGAARD |