Benzisoxazoles

摘要

The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents an integer from 1 to 3; X represents amino, hydroxy, -oxo or -Z-R¹; Y is absent when X represents -Z-R¹ and -(C-O)-R⁶ when X represents oxo; Z represents carbonyl, -oxy-carbonyl- or -NR⁵-carbonyl-; R¹ represents C_1-4alkyl, Ar¹, Ar¹-C_1-4alkyl-, -NR³R⁴ or -Het¹; R² represents hydrogen, halo, nitro, hydroxycarbonyl-, C_1-4alkyloxy or C_1-4alkyl; R³ and R⁴ are each independently selected from hydrogen, Ar³ or C_1-4alkyl; R⁵ represents hydrogen, C_1-4alkylcarbonyl- or Ar⁴-carbonyl-; R⁶ represents a substituent selected from the group consisting of C_1-4alkyl, Ar⁵, Ar⁶-C_1-4alkyl- or NR⁷R⁸; R⁷ and R⁸ are each independently selected from hydrogen, Het⁴ or C_1-4alkyl; Het¹ represents a heterocycle selected from oxazolyl, isoxazolyl, imidazolyl or pyrazolyl wherein said heterocycle is optionally substituted with one, two or three substitutents selected from the group consisting of amino, C_1-4alkyl, hydroxy-C_1-4alkyl, phenyl, phenyl-C_1-4alkyl- and phenyl substituted with one or more halo substitutents; Het⁴ represents a heterocycle selected from oxazolyl or isoxazolyl, wherein said heterocycle is optionally substituted with one or more substitutents selected from the group consisting of amino, C_1-4alkyl, hydroxy-C_1-4alkyl-, phenyl, phenyl-C_1-4alkyl and phenyl substituted with one or more halo substitutents; and Ar¹, Ar², Ar³, Ar⁴, Ar⁵ or Ar⁶ each independently represents phenyl optionally substituted one or where possible two or more substitutents selected from halo, nitro, C_1-4alkyl, hydroxy or C_1-4alkyloxy-.