发明名称 |
Method of detecting AZT resistance in HIV |
摘要 |
Described herein is a method of determining the presence of a nucleoside reverse transcriptase inhibitor-resistant Human Immunodeficiency Virus-1 (HIV-1) virus particle in a biological sample, comprising identifying the presence in the sample of a point mutation at codon Q509 of an HIV-1 reverse transcriptase, for example and without limitation Q509L. That point mutation increases resistance to AZT about 3- to 10-fold by itself and about 50-fold in combination with the connection domain mutation A371V.
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申请公布号 |
US2007196902(A1) |
申请公布日期 |
2007.08.23 |
申请号 |
US20070699941 |
申请日期 |
2007.01.30 |
申请人 |
UNIVERSITY OF PITTSBURGH |
发明人 |
MELLORS JOHN W.;KOONTZ DIANNA;BREHM JESSICA H. |
分类号 |
C12Q1/68;C12N5/06;C12N5/16;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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