发明名称 |
IGF-1 INSTRUCTS MULTIPOTENT ADULT CNS NEURAL STEM CELLS TO AN OLIGODENDROGLIAL LINEAGE |
摘要 |
Adult neural stem cells differentiate into neurons, astrocytes, and oligodendrocytes in the mammalian CNS, but the molecular mechanisms that control their differentiation are not yet well understood. Insulin-like growth factor-I (IGF-I) can promote the differentiation of cells already committed to an oligodendroglial lineage during development. However, it is unclear whether IGF-I affects multipotent neural stem cells. Here we show that IGF-I stimulates the differentiation of multipotent adult rat hippocampus-derived neural progenitor cells into oligodendrocytes. Modeling analysis indicates that the actions of IGF-I are instructive. Oligodendrocyte differentiation by IGF-I appears to be mediated through an inhibition of BMP signaling. Furthermore, overexpression of IGF-I in the hippocampus leads to an increase in oligodendrocyte markers. These data demonstrate the existence of a single molecule, IGF-I, that can influence the fate choice of multipotent adult neural progenitor cells to an oligodendroglial lineage. |
申请公布号 |
WO2005030932(A3) |
申请公布日期 |
2007.08.23 |
申请号 |
WO2004US31426 |
申请日期 |
2004.09.24 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;GAGE, FRED H.;HSIEH, JENNY |
发明人 |
GAGE, FRED H.;HSIEH, JENNY |
分类号 |
C12N5/00;C12N;C12N5/079;C12P21/00 |
主分类号 |
C12N5/00 |
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